Functional characterization of TcCYC2 cyclin from Trypanosoma cruzi

► The cyclin TcCYC2 from Trypanosoma cruzi was characterized. ► TcCYC2 gene complemented G1-cyclin activity in yeast. ► Recombinant TcCYC2-HA expression shortened the cell cycle of T. cruzi epimastigotes. ► TcCYC2-HA expression altered duplication time and morphology of T. cruzi. ► TcCYC2-HA was expressed mainly in the cytoplasm of T. cruzi.