Effect of repetitiveness on the immunogenicity and antigenicity of Trypanosoma cruzi FRA protein

► The number of T. cruzi FRA tandem repeats did not increase its immunogenicity. ► The number of T. cruzi FRA tandem repeats favored its recognition by antibodies. ► FRA motif shows a pattern of three alpha-helices connected by two loops. ► The main epitope from the antigen would be in a loop of the motif.