کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6292293 | 1302523 | 2011 | 8 صفحه PDF | دانلود رایگان |
The present research was performed to isolate and study the effects of a low molecular weight (<1300Â Da) parasite-associated substance, obtained from peritoneal fluids of female mice infected with Taenia crassiceps cysticerci, on seminiferous epithelium cells of male mice testis. The results showed an intense disruption of Sertoli cells and germ cells within the seminiferous tubules of experimental mice, along with the destruction of their gap junction (GJ). Significant generalized apoptosis of germ cells within seminiferous tubules was determined by TUNEL staining (PÂ =Â 0.0159). In addition, a significant number of infiltrating macrophages were found in the luminal space of these seminiferous tubules (PÂ <Â 0.0001). Finally, electron microscopy studies revealed structural and morphological abnormalities in the somatic cells (Sertoli and Leydig cells) and in the germ cells, primarily in the round and elongate spermatids.
Highlights⺠A Taenia crassiceps secretion-substance of low molecular weight leads to severe pathology in testis of mice. ⺠Generalized apoptosis of germ cells within the seminiferous tubules. ⺠A significant infiltration of macrophages within seminiferous tubules. ⺠Deformity of sperm heads cells.
Journal: Experimental Parasitology - Volume 128, Issue 3, July 2011, Pages 184-191