کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6308796 | 1618859 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioavailability and pharmacokinetics of arsenic are influenced by the presence of cadmium
ترجمه فارسی عنوان
قابلیت دسترسی بیولوژیک و فارماکوکینتیک آرسنیک تحت تأثیر حضور کادمیم است
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کلمات کلیدی
آرسنیک، کادمیوم، قابلیت دسترسی بیولوژیک، فارماکوکینتیک، اثر متقابل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Mine wastes contain a mixture of metals and metalloids including arsenic (As) and cadmium (Cd). This study investigated the potential interaction between As and Cd in a rat model. Sprague Dawley rats were dosed with sodium arsenate via the oral (0, 0.5, 5 and 15Â mg As kgâ1 b.w.) or intravenous (0.5Â mg As kgâ1 b.w.) route to establish its dose-response relationship in terms of bioavailability and pharmacokinetic parameters. Bioavailability of As reduced when the dose of As increased. For the interaction study a fixed oral dose of As at 2.5Â mg As kgâ1 b.w. solo and in combination with Cd as cadmium chloride at 3 or 6Â mg Cd kgâ1 b.w. were administered to rats. Bioavailability of As was decreased by 34-35% in the presence of Cd. Elimination half-life of As was also decreased from 69 days in the As solo group to 13-22Â days in the presence of 3 and 6Â mg Cd kgâ1 b.w. respectively. Decreased urinary excretion of As and tissue accumulation were also observed. A probable explanation for these findings is that As co-administration with Cd could have resulted in the formation of less soluble cadmium-arsenic complexes in the guts of the rats. Nevertheless, such an interaction between As and Cd could only explained about 44-48% of the variation when mine waste materials containing both of these elements were administered to rats. This suggests other physical properties and chemical compound formation could contribute to the observed bioavailability of arsenic in complex environmental samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 112, October 2014, Pages 203-209
Journal: Chemosphere - Volume 112, October 2014, Pages 203-209
نویسندگان
Violet Diacomanolis, Barry N. Noller, Jack C. Ng,