کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6308871 1618859 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus
چکیده انگلیسی
Bisphenol A (BPA), an estrogenic monomer, has attracted many researchers to study its adverse effects in animal reproduction, especially in fish. To explore the effects of low dose BPA on adult female rare minnow Gobiocypris rarus, we exposed the fish to BPA at nominal concentrations of 5, 15, and 50 μg L−1 for 14 and 35 d. The 35-d BPA exposure at 50 μg L−1 had obviously suppressive effects on oocyte development, and BPA at all the three concentrations in both exposure durations of 14 and 35 d had stimulative effects on hepatic vitellogenin (vtg) transcription. BPA at lower concentrations (5 and 15 μg L−1) exhibited stimulative effects on the expressions of ovarian steroidogenic genes while at higher concentration (50 μg L−1) displayed inhibitive effects. Analysis of ovarian steroidogenic genes 5′-flanking regions and mRNA expressions of their potential regulatory factors revealed that the BPA-mediated actions on steroidogenesis in G. rarus ovary probably involve estrogen receptor (Esr) and androgen receptor (Ar) signaling, nuclear receptor subfamily 5, group A, number 1 (Nr5a1) pathway, and epigenetic regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 112, October 2014, Pages 435-442
نویسندگان
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