کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6308871 | 1618859 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
Bisphenol A (BPA), an estrogenic monomer, has attracted many researchers to study its adverse effects in animal reproduction, especially in fish. To explore the effects of low dose BPA on adult female rare minnow Gobiocypris rarus, we exposed the fish to BPA at nominal concentrations of 5, 15, and 50 μg Lâ1 for 14 and 35 d. The 35-d BPA exposure at 50 μg Lâ1 had obviously suppressive effects on oocyte development, and BPA at all the three concentrations in both exposure durations of 14 and 35 d had stimulative effects on hepatic vitellogenin (vtg) transcription. BPA at lower concentrations (5 and 15 μg Lâ1) exhibited stimulative effects on the expressions of ovarian steroidogenic genes while at higher concentration (50 μg Lâ1) displayed inhibitive effects. Analysis of ovarian steroidogenic genes 5â²-flanking regions and mRNA expressions of their potential regulatory factors revealed that the BPA-mediated actions on steroidogenesis in G. rarus ovary probably involve estrogen receptor (Esr) and androgen receptor (Ar) signaling, nuclear receptor subfamily 5, group A, number 1 (Nr5a1) pathway, and epigenetic regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 112, October 2014, Pages 435-442
Journal: Chemosphere - Volume 112, October 2014, Pages 435-442
نویسندگان
Yingying Zhang, Jiancao Gao, Peng Xu, Cong Yuan, Fang Qin, Shaozhen Liu, Yao Zheng, Yanping Yang, Zaizhao Wang,