کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6309371 1645519 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats
ترجمه فارسی عنوان
اثر محافظتی بور بر روی پراکسیداسیون لیپید ناشی از سیکلوفسفامید و سمیت نسبی در موش صحرایی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
The aim of the present study was to evaluate the possible protective effect of boron (B) on cyclophosphamide (CYC) induced oxidative stress in rats. Totally, thirty Wistar albino male rats were fed standard rodent diet and divided into 5 equal groups: physiological saline was given intraperitoneally (i.p.) to the control group (vehicle treated), to the second group only 75 mg kg−1 CYC was given i.p. on the 14th d, and boron was administered (5, 10, and 20 mg kg−1, i.p.) to the other groups for 14 d and CYC (75 mg kg−1, i.p.) on the 14th d. CYC caused increase of malondialdehyde and decrease of glutathione levels, decrease of superoxide dismutase activities in erythrocyte and tissues, decrease of erythrocyte, heart, lung, and brain catalase, and plasma antioxidant activities. Also, CYC treatment caused to DNA damage in mononuclear leukocytes. Moreover, B exhibited protective action against the CYC-induced histopathological changes in tissues. However, treatment of B decreased severity of CYC-induced lipid peroxidation and genotoxicity on tissues. In conclusion, B has ameliorative effects against CYC-induced lipid peroxidation and genotoxicity by enhancing antioxidant defence mechanism in rat.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 108, August 2014, Pages 197-204
نویسندگان
, , , , , ,