کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6309382 | 1645519 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri Experimental and predicted acute toxicity of antibacterial compounds and their mixtures using the luminescent bacterium Vibrio fischeri](/preview/png/6309382.png)
چکیده انگلیسی
This article investigates the bioluminescence inhibition effects of the antimicrobials triclocarban, triclosan and its metabolite methyl triclosan, using the marine bacterium Vibrio fischeri as the test organism (Microtox©). The concentration response analysis was performed for the three individual substances and for a mixture in which the three compounds were mixed in a ratio of the IC50 of the individual components (equitoxic ratio). Toxicity values (the median inhibitory concentration value, in mg Lâ1) in the decreasing order of sensitivity were triclosan (0.73) > triclocarban (0.91) > methyl-triclosan (1.76). The comparison of the experimental data with those obtained by using Quantitative Structure-Activity Relationship (QSAR) equations indicated that triclosan and triclocarban act as polar narcotic compounds towards V. fischeri, whereas methyl-triclosan acts as a narcotic (baseline toxicity). The toxicity of the mixture was measured experimentally and predicted by two models (CA: concentration addition; IA: independent action). The results showed that the observed mixture toxicity (IC50 = 0.23 mg Lâ1) had no significant differences from those predicted by both CA and IA models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 108, August 2014, Pages 239-244
Journal: Chemosphere - Volume 108, August 2014, Pages 239-244
نویسندگان
Sara Villa, Marco Vighi, Antonio Finizio,