کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6309591 | 1307453 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of anti-anxiety and anti-epileptic drugs in hospital effluent and a preliminary risk assessment
ترجمه فارسی عنوان
تعیین ضد اضطراب و داروهای ضد صرع در پساب بیمارستان و ارزیابی خطر اولیه
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
In this study, an analytical methodology was developed for the determination of psycho-active drugs in the treated effluent of the University Hospital at the Federal University of Santa Maria, RS - Brazil. Samples were collected from point A (Emergency) and point B (General effluent). The adopted methodology included a pre-concentration procedure involving the use of solid phase extraction and determination by liquid chromatography coupled to mass spectrometry. The limit of detection for bromazepam and lorazepam was 4.9 ± 1.0 ng Lâ1 and, for carbamazepine, clonazepam and diazepam was 6.1 ± 1.5 ng Lâ1. The limit of quantification was 30.0 ± 1.1 ng Lâ1, for bromazepam, clonazepam and lorazepam; for carbamazepine was 50.0 ± 1.8 ng Lâ1 and was 40.0 ± 1.0 ng Lâ1 for diazepam. The mean concentrations in the Emergency and General effluent treated currents were as follows: for bromazepam, 195 ± 6 ng Lâ1 and 137 ± 7 ng Lâ1; for carbamazepine, 590 ± 6 ng Lâ1 and 461 ± 10 ng Lâ1; for diazepam, 645 ± 1 ng Lâ1 and 571 ± 10 ng Lâ1; for lorazepam, 96 ± 7 ng Lâ1 and 42 ± 4 ng Lâ1; and for clonazepam, 134 ± 10 ng Lâ1 and 57 ± 10 ng Lâ1. A preliminary risk assessment was conducted: carbamazepine and diazepam require considerable attention owing to their environmental toxicity. The occurrence of these psychoactive-drugs and the environmental risks that they pose demonstrated the need for a more efficient treatment system. As far we are aware, there have been no comparable studies to this on the hazards of hospital effluents in Brazil, and very few that have carried out a risk assessment of psycho-active drugs in hospital effluent in general.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2349-2355
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2349-2355
نویسندگان
Carlos Alberto A. de Almeida, Carla G.B. Brenner, Luciane Minetto, Carlos A. Mallmann, Ayrton F. Martins,