Genetic susceptibility to dioxin-like chemicals' induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism

► AhR, ARNT, and AhRR play important roles for dioxin-like chemicals signaling. ► CYP1A2 induction is an excellent biomarker of dioxin-like chemicals exposure. ► We study the blood samples from a highly dioxin-like chemicals exposed cohort. ► AhRR genetic polymorphisms are significant related to CYP1A2 induction. ► AhRR genetic polymorphisms predict susceptibility to dioxin-like chemicals.