A comparison of octanol-water partitioning between organic chemicals and their metabolites in mammals

► We focus on the most common biotransformation reactions in mammals. ► We compare the log Kow of organic pollutants with the log Kow of their metabolites. ► The log Kow decreases by a factor between 0 and −2, depending on the reaction. ► The trends with predicted log Kow are validated using experimental log Kow. ► The quantification of Kow reduction may improve bioaccumulation models.