Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol

► Two-year cancer bioassays in rodents given dietary 2,4,6-trichlorophenol. ► Dietary levels to Fischer rats and B6C3F1 mice of 0%, 0.5%, 1.0% 2,4,6-TCP. ► Leukocytosis/monocytosis of peripheral blood, hyperplasia of bone marrow in rats. ► Liver cell abnormalities, altered foci, nodular hyperplasia in mice. ► 2,4,6-Trichlorophenol exposures associated with leukemia/lymphoma and liver tumors.