A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities

► Arsenic induced osmotic stress and disturbance in energy metabolism in clam. ► Arsenic caused only disturbance in energy metabolism in clam under low salinity. ► Salinity influenced metabolic responses induced by arsenic in clam muscle. ► Environmental factors should be considered in ecotoxicology studies.