کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6312757 | 1619036 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status
ترجمه فارسی عنوان
ارتباط مواد پرفرولاوآلکلیک با سطوح هورمون تولید مثل در نوجوانان: براساس وضعیت جنس
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کلمات کلیدی
PFOSPFHpAperfluorododecanoic acidPerfluorotetradecanoic acidPerfluoroheptanoic acidPolyfluoroalkyl substancesPFDoAPFDAPFNAperfluorohexane sulfonatePFHxAPFBSPFHxSPFASsPerfluorobutane sulfonatePFOA95%CI - 95٪ CIEstradiol - استرادیولperfluorodecanoic acid - اسید perfluorodecanoicPerfluorononanoic acid - اسید Perfluorononanoictestosterone - تستوسترونSex - جنسیت، رابطه ی جنسیPerfluorooctane sulfonate - سولفونات Perfluorooctane95% confidence intervals - فاصله اطمینان 95٪Perfluoroalkyl substances - مواد PerfluoroalkylAdolescents - نوجوانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Polyfluoroalkyl substances (PFASs) are a group of common chemicals that ubiquitously exist in wildlife and humans. However, few studies have researched the effect of PFASs on reproductive hormones in adolescents. To provide information in this regard, we recruited 225 Taiwanese adolescents aged 13-15 years from 2009 to 2010 to investigate the relationship between serum PFASs (PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxA, PFHxS, PFNA and PFTA) and reproductive hormone concentrations using a cross-sectional study design. Results showed PFOS and PFTA levels were highest among the PFASs, with a median concentrations of 29.9 (interquartile range: 13.0-43.8) ng/mL and 6.0 (0.6-25.9) ng/mL in males, and a median concentrations of 28.8 (14.8-42.6) ng/mL and 4.5 (0.3-18.4) ng/mL in females. After adjustment for confounding factors, nonsignificant associations between PFASs and reproductive hormone were found except for PFNA with ln(estradiol) (β = 0.2060, 95%CI: 0.0016, 0.4105). When stratified by sex, more significant associations were found in males than in females. Among males, PFASs were negatively associated with ln(testosterone) level for PFOS (β = â 0.0029, 95%CI: â 0.0055, â 0.0003), PFDA (β = â 0.2565, 95%CI: â 0.4135, â 0.0994), PFHxA (β = â 0.3095, 95%CI: â 0.5942, â 0.0248), and PFNA (β = â 0.4233, 95%CI: â 0.6998, â 0.1467). Furthermore, male participant ln(estradiol) levels were positively associated with PFOA (β = 0.0921, 95%CI: 0.0186, 0.1656), and PFHxS (β = 0.0462, 95%CI: 0.0020, 0.0905). Among females, a significant relationship was found only for PFDoA with ln(testosterone) (β = â 0.0119, 95%CI: â 0.0227, â 0.0010). In conclusion, this study showed higher levels of PFASs coincide with lower testosterone and higher estradiol levels, and more significant associations of PFASs with reproductive hormone were found in males than in females.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 94, September 2016, Pages 189-195
Journal: Environment International - Volume 94, September 2016, Pages 189-195
نویسندگان
Yang Zhou, Li-Wen Hu, Zhengmin (Min) Qian, Jen-Jen Chang, Chris King, Gunther Paul, Shao Lin, Pau-Chung Chen, Yungling Leo Lee, Guang-Hui Dong,