Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities

► Study identified discrete gene sets in vitro by PCBs human equivalence exposures. ► Identified genes that were differentially expressed for each agent individually. ► Identified candidate genes and pathways for disease and disorder susceptibility. ► Revealed Molecular mechanisms, and its functional effects, following PCB exposure. ► Potential use of these genomic signatures in disease susceptibility and risk.