کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6325998 | 1619748 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1Â year of age
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کلمات کلیدی
PCDDsPCDFsDDITEQTEF2,3,4,7,8-pentachlorodibenzofuran2,3,7,8-Tetrachlorodibenzo-p-dioxin - 2،3،7،8-تترا کلریدیبنزوپتوفان دیوکسین2,3,7,8-tetrachlorodibenzofuran - 2،3،7،8-تتراکلرویدید بنزوفورانPolychlorinated dibenzofurans - dibenzofurans پلی کربناتneurodevelopment - توسعه عصبیPolychlorinated dibenzo-p-dioxins - دی بنزوپروتئینهای پلی کربناتDioxin - دیوکسینToxic equivalent factors - عوامل موثر سمیToxic equivalent - معادل سمیVietnam - ویتنامToddler - کودک نو پا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dioxin concentrations remain elevated in both the environment and in humans residing near former US Air Force bases in South Vietnam. This may potentially have adverse health effects, particularly on infant neurodevelopment. We followed 214 infants whose mothers resided in a dioxin-contaminated area in Da Nang, Vietnam, from birth until 1Â year of age. Perinatal exposure to dioxins was estimated from toxic equivalent (TEQ) levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDDs/Fs-TEQ), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TetraCDD) concentrations in breast milk. In infants, daily dioxin intake (DDI) was used as an index of postnatal exposure through breastfeeding. Neurodevelopment of toddlers was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). No significant differences in neurodevelopmental scores were exhibited for cognitive, language or motor functions between four exposure groups of PCDDs/Fs-TEQ or 2,3,7,8-TetraCDD. However, social-emotional scores were decreased in the high PCDDs/Fs-TEQ group and the high 2,3,7,8-TetraCDD group compared with those with mild exposure, after adjusting for confounding factors. Cognitive scores in the mild, moderate, and high DDI groups were significantly higher than those in low DDI group, but there were no differences in cognitive scores among the three higher DDI groups. These results suggest that perinatal exposure to dioxins may affect social-emotional development of 1-year-old toddlers, without diminishing global neurodevelopmental function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 536, 1 December 2015, Pages 575-581
Journal: Science of The Total Environment - Volume 536, 1 December 2015, Pages 575-581
نویسندگان
Tai The Pham, Muneko Nishijo, Anh Thi Nguyet Nguyen, Nghi Ngoc Tran, Luong Van Hoang, Anh Hai Tran, Trung Viet Nguyen, Hisao Nishijo,