کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6332775 | 1619798 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sildenafil and tadalafil in simulated chlorination conditions: Ecotoxicity of drugs and their derivatives
ترجمه فارسی عنوان
سیلدنافیل و تادالافیل در شرایط کلر زنی شبیه سازی شده: سمیت مواد زیستی و مشتقات آن
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کلمات کلیدی
سیلدنافیل، تادالافیل، کلر زنی، تست سمیت حاد و مزمن، موتاژنز، سمیت ژنتیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Chlorination experiments on two drugs (sildenafil and tadalafil) were performed mimicking the conditions of a typical wastewater treatment process. The main transformation products were isolated by chromatographic techniques (Thin Layer Chromatography (TLC), Column Chromatography (CC), High Performance Liquid Chromatography (HPLC)) and fully characterized employing Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) analyses. The environmental effects of the parent compounds and transformation products were evaluated using an overall toxicity approach that considered aquatic acute and chronic toxicity on Brachionus calyciflorus and Ceriodaphnia dubia as well as mutagenesis and genotoxicity on bacterial strains. The results revealed that both parent drugs did not show high acute and chronic toxicity for the organisms utilized in the bioassays while, chronic exposure to chlorine derivatives caused inhibition of growth population on rotifers and crustaceans. A mutagenic potential was found for all the compounds investigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 463â464, 1 October 2013, Pages 366-373
Journal: Science of The Total Environment - Volumes 463â464, 1 October 2013, Pages 366-373
نویسندگان
Fabio Temussi, Marina DellaGreca, Paola Pistillo, Lucio Previtera, Armando Zarrelli, Emma Criscuolo, Margherita Lavorgna, Chiara Russo, Marina Isidori,