کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6336137 | 1620334 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exposure to daily ambient particulate polycyclic aromatic hydrocarbons and cough occurrence in adult chronic cough patients: A longitudinal study
ترجمه فارسی عنوان
قرار گرفتن در معرض هیدروکربن های آروماتیک چند حلقه ای روزانه محیطی و وقوع سرفه در بیماران مبتلا به سرفه مزمن: یک مطالعه طولی
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کلمات کلیدی
CVAparticulate matter less than 10 μm in aerodynamic diameterDEPsIL-8CYP1A1IQRTSPPM10PM2.5PAHTRPA1Asthma - آسمInterleukin-8 - اینترلوکین -8Adult patients - بزرگسالانGEE - جیDiesel exhaust particles - ذرات خروجی دیزلparticulate matter - ذرات معلقAtopic cough - سرفه اتوپیکconfidence interval - فاصله اطمینانTNF-α - فاکتور نکروز توموری آلفاTotal suspended particles - مجموع ذرات معلقinterquartile range - محدوده بین محدبgeneralized estimating equation - معادله تخمین کلیCough variant asthma - نوع آسم سرفهNitric oxide - نیتریک اکسیدPolycyclic aromatic hydrocarbon - هیدروکربن آروماتیک چند حلقه ایPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایtransient receptor potential ankyrin 1 - پتانسیل گیرنده گذرا ankyrin 1high performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
علم هواشناسی
چکیده انگلیسی
The specific components of airborne particulates responsible for adverse health effects have not been conclusively identified. We conducted a longitudinal study on 88 adult patients with chronic cough to evaluate whether exposure to daily ambient levels of particulate polycyclic aromatic hydrocarbons (PAH) has relationship with cough occurrence. Study participants were recruited at Kanazawa University Hospital, Japan and were physician-diagnosed to at least have asthma, cough variant asthma and/or atopic cough during 4th January to 30th June 2011. Daily cough symptoms were collected by use of cough diaries and simultaneously, particulate PAH content in daily total suspended particles collected on glass fiber filters were determined by high performance liquid chromatography coupled with fluorescence detector. Population averaged estimates of association between PAH exposure and cough occurrence for entire patients and subgroups according to doctor's diagnosis were performed using generalized estimating equations. Selected adjusted odds ratios for cough occurrence were 1.088 (95% confidence interval (CI): 1.031, 1.147); 1.209 (95% CI: 1.060, 1.379) per 1Â ng/m3 increase for 2-day lag and 6-day moving average PAH exposure respectively. Likewise, 5 ring PAH had higher odds in comparison to 4 ring PAH. On the basis of doctor's diagnosis, non-asthma group had slightly higher odds ratio 1.127 (95% CI: 1.033, 1.228) per 1Â ng/m3 increase in 2-day lag PAH exposure. Our findings suggest that ambient PAH exposure is associated with cough occurrence in adult chronic cough patients. The association may be stronger in non-asthma patients and even at low levels although there is need for further study with a larger sample size of respective diagnosis and inclusion of co-pollutants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atmospheric Environment - Volume 140, September 2016, Pages 34-41
Journal: Atmospheric Environment - Volume 140, September 2016, Pages 34-41
نویسندگان
Enoch Olando Anyenda, Tomomi Higashi, Yasuhiro Kambayashi, Nguyen Thi Thu Thao, Yoshimasa Michigami, Masaki Fujimura, Johsuke Hara, Hiromasa Tsujiguchi, Masami Kitaoka, Hiroki Asakura, Daisuke Hori, Yohei Yamada, Koichiro Hayashi, Kazuichi Hayakawa,