کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6352632 | 1622564 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma
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کلمات کلیدی
di-2-ethylhexyl phthalate(MMP)(mCPP)mono-2-ethylhexyl phthalate(CI)(BMI)mono-(2-ethyl-5-carboxypentyl) phthalatemono-n-octyl phthalatemono-n-butyl phthalatemono-(3-carboxypropyl) phthalate(OR)mono-cyclohexyl phthalate2-Hydroxy-4-methoxybenzophenone - 2-هیدروکسی 4-متیل اکسید بنفنون2,4-dihydroxybenzophenone - 2،4-دی هیدروکسی بنزوفنون4-hydroxybenzophenone - 4-هیدروکسی بنزوفنونmono-(2-ethyl-5-hydroxyhexyl) phthalate - mono (2-ethyl-5-hydroxyhexyl) phthalatemono-(2-ethyl-5-oxohexyl) phthalate - mono (2-ethyl-5-oxohexyl) phthalateNational Health and Nutrition Examination Survey - بررسی بهداشت و تغذیه ملیBenzophenone - بنزوفنونMono-benzyl phthalate - بنزیل فتالاتBisphenol A - بیسفنول ای، بیسفنول APolycystic ovary syndrome - سندرم تخمدان پلی کیستیکbody mass index - شاخص توده بدنconfidence interval - فاصله اطمینانPhthalate - فتالات، استرهای فتالاتfibroid - فیبروئیدUltraviolet filter - فیلترهای اشعه ماوراء بنفشmono-ethyl phthalate - متیل فتالاتmono-isobutyl phthalate - مونو ایزوبوتیل فتالاتmono-methyl phthalate - مونو متیل فتالاتmono-isononyl phthalate - مونیزونونیل فتالاتodds ratio - نسبت شانس ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Bisphenol A, benzophenone-type UV filters, and phthalates are chemicals in high production and use including in a range of personal care products. Exposure of humans to these chemicals has been shown to affect endocrine function. Although short-lived, widespread exposure may lead to continual opportunity for these chemicals to elicit health effects in humans. The association of these chemicals with incident uterine leiomyoma, an estrogen sensitive disease, is not known. Urinary concentrations of bisphenol A (BPA), five benzophenone-type UV filters (2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone (2,4OH-BP), 2,2׳-dihydroxybenzophenone (2,2׳OH-4MeO-BP), 2,2׳4,4׳-tetrahydroxybenzophenone (2,2׳4,4׳OH-BP), and 4-hydroxybenzophenone (4OH-BP), and 14 phthalate monoesters were quantified in 495 women who later underwent laparoscopy/laparotomy at 14 clinical sites for the diagnosis of fibroids. Significantly higher geometric mean creatinine-corrected concentrations of BPA, 2,4OH-BP, and 2OH-4MeO-BP were observed in women with than without fibroids [BPA: 2.09 µg/g vs. 1.46 µg/g p=0.004; 2,4OH-BP:11.10 µg/g vs. 6.71 µg/g p=0.01; 2OH-4MeO-BP: 11.31 µg/g vs. 6.10 µg/g p=0.01]. Mono-methyl phthalate levels were significantly lower in women with than without fibroids (1.78 µg/g vs. 2.40 µg/g). However, none of the exposures were associated with a significant odds ratio even when adjusting for relevant covariates. There was a lack of an association between select nonpersistent chemicals and the odds of a fibroid diagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 137, February 2015, Pages 101-107
Journal: Environmental Research - Volume 137, February 2015, Pages 101-107
نویسندگان
A.Z. Pollack, G.M. Buck Louis, Z. Chen, L. Sun, B. Trabert, Y. Guo, K. Kannan,