کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6352632 1622564 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma
چکیده انگلیسی
Bisphenol A, benzophenone-type UV filters, and phthalates are chemicals in high production and use including in a range of personal care products. Exposure of humans to these chemicals has been shown to affect endocrine function. Although short-lived, widespread exposure may lead to continual opportunity for these chemicals to elicit health effects in humans. The association of these chemicals with incident uterine leiomyoma, an estrogen sensitive disease, is not known. Urinary concentrations of bisphenol A (BPA), five benzophenone-type UV filters (2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone (2,4OH-BP), 2,2׳-dihydroxybenzophenone (2,2׳OH-4MeO-BP), 2,2׳4,4׳-tetrahydroxybenzophenone (2,2׳4,4׳OH-BP), and 4-hydroxybenzophenone (4OH-BP), and 14 phthalate monoesters were quantified in 495 women who later underwent laparoscopy/laparotomy at 14 clinical sites for the diagnosis of fibroids. Significantly higher geometric mean creatinine-corrected concentrations of BPA, 2,4OH-BP, and 2OH-4MeO-BP were observed in women with than without fibroids [BPA: 2.09 µg/g vs. 1.46 µg/g p=0.004; 2,4OH-BP:11.10 µg/g vs. 6.71 µg/g p=0.01; 2OH-4MeO-BP: 11.31 µg/g vs. 6.10 µg/g p=0.01]. Mono-methyl phthalate levels were significantly lower in women with than without fibroids (1.78 µg/g vs. 2.40 µg/g). However, none of the exposures were associated with a significant odds ratio even when adjusting for relevant covariates. There was a lack of an association between select nonpersistent chemicals and the odds of a fibroid diagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 137, February 2015, Pages 101-107
نویسندگان
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