Constraints on the use of lifespan-shortening Wolbachia to control dengue fever

► We model the spatial spread of lifespan-shortening Wolbachia. ► Lifespan-shortening Wolbachia is a potential control strategy for dengue fever. ► Lifespan-shortening and fecundity-reducing Wolbachia have different effects on spatial spread. ► Empirically estimated parameters suggest that lifespan-shortening Wolbachia will not spread in the wild.