کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6372182 | 1319980 | 2012 | 13 صفحه PDF | دانلود رایگان |
New models of gene transcriptional responses to auxin signalling in Arabidopsis are presented. This work extends a previous model of auxin signalling to include networks of gene-sets which may control developmental responses along auxin gradients. Key elements of this new study include models of signalling pathways and networks involving two Aux-IAA proteins (IAAs), auxin response factors (ARFs) and gene targets. Hypotheses for the gene network topologies which may be involved in developmental responses have been tested against experimental observations for root hair growth in particular. In studying these models, we provide a framework for the analysis of auxin signalling with multiple IAAs and ARFs, and discuss the implications of bistability in such systems.
⺠We present new models of gene transcriptional responses to auxin signalling in plants. ⺠We study gene regulatory network models which may be responsible for developmental responses. ⺠Models of pathways include two Aux-IAA proteins, auxin response factors and gene targets. ⺠Hypotheses are tested against published experimental observations. ⺠We discuss the implications of bistability in such systems.
Journal: Mathematical Biosciences - Volume 235, Issue 1, January 2012, Pages 32-44