Estrogen receptor-hijacking by dioxin-like 3,3′4,4′,5-pentachlorobiphenyl (PCB126) in salmon hepatocytes involves both receptor activation and receptor protein stability

► Mechanisms of ER hijacking by dioxin-like PCB congener 126. ► Cycloheximide stimulation of coordinated recruitment of the proteasome complex. ► Ubiquitination and degradation of ER and AhR isoforms and downstream protein products. ► Positive 3′,4′-dimethoxyflavone (DMF) effects on the AhR signalling pathway. ► Role of receptor activation and receptor-protein stability.