کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
638923 883729 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Morphology and permeability of cellulose/chitin blend membranes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
Morphology and permeability of cellulose/chitin blend membranes
چکیده انگلیسی
A series of biodegradable cellulose/chitin blend membranes were successfully prepared from blend solution of cellulose and chitin in 9.5 wt% NaOH/4.5 wt% thiourea aqueous solution coagulating with 5.0 wt% (NH4)2SO4. The influence of chitin content on the morphology and structure of the membranes was studied by scanning electron microscopy, environmental scanning electron microscopy and wide-angle X-ray diffractometry, as well as Fourier transform infrared spectroscopy. Using double-cell method and solution depletion method, the permeability and partition coefficients of three model drugs (ceftazidine, cefazolin sodium, and thiourea) were determined in phosphate buffer solution to clarify the diffusion mechanism governing transport of solutes in these membranes. Diffusion coefficients were calculated from the permeability and partition coefficients in terms of Fick's law. The effects of the chitin content, pH, ionic strength, molecular size and temperature on the drug diffusion were also studied. Our results revealed that all of the membranes had a porous-like structure. The introduction of chitin exhibited great influence on the morphology and crystal structure of the blend membranes, resulting in a significant different permeability. For the first time, a dual diffusion mechanism with some hindrance of molecular diffusion via polymer obstruction was employed to explain the transport of drugs in the membranes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 287, Issue 1, 5 January 2007, Pages 19-28
نویسندگان
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