کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6399975 1330716 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of brown rice, rice bran, and polished rice on colon carcinogenesis in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Effects of brown rice, rice bran, and polished rice on colon carcinogenesis in rats
چکیده انگلیسی

Rice is a nutritious staple food with health-promoting activity. This study investigated the effects of brown rice, rice bran, and polished rice on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. The colons were examined for preneoplastic lesions and the expression of pro-inflammatory proteins. Lipid peroxidation was determined in livers and plasma; antioxidant-associated parameters were determined in livers. The results showed that consumption of medium-level of rice bran significantly reduced the number of aberrant crypt foci (ACF) and altered their distribution. Brown rice and rice bran significantly reduced cyclooxygenase-2 (COX-2) expression of the middle colon. Brown rice, rice bran, and polished rice had no significant effect on plasma and hepatic lipid peroxides and hepatic antioxidant-associated parameters. Thus, rice bran may be one candidate of the active rice fraction that protects the colon against DMH-induced early carcinogenesis in rats and may be a novel dietary supplement for chemoprevention of colon cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Research International - Volume 44, Issue 1, January 2011, Pages 209-216
نویسندگان
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