کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
646344 884561 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acrylic acid controlled reusable temperature-sensitive hydrogel phantoms for thermal ablation therapy
ترجمه فارسی عنوان
اسید اکریلیک فانتوم های هیدروژل حساس به درجه حرارت قابل استفاده مجدد برای درمان حرارتی تخلیه را کنترل می کند
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
چکیده انگلیسی


• A method to fabricate a transparent reusable tissue-mimicking phantom was proposed.
• The phantom changes color at a preselected threshold temperature.
• The threshold temperature can be adjusted by the concentration of acrylic acid.
• The phantom was designed for the real-time visualization of thermal lesions.

Polymerization of N-isopropylacrylamide (NIPAM) with acrylic acid (AAc) has been adopted to fabricate reusable tissue-mimicking hydrogel phantoms designed for the real-time visualization and examination of thermal lesion formation in ablation and hyperthermia therapies. It is shown that the cloud point temperature of the NIPAM-based hydrogel phantoms can be adjusted by the concentration of AAc to represent the threshold temperature of pain (42 °C) or tissue damage (52 °C). The mechanical, thermal and acoustic properties of the developed phantoms are similar to those of human soft tissues. The ability of the phantoms to provide visualization of thermal lesions produced by either microwave or high-intensity focused ultrasound (HIFU) ablation was examined. Evolution of the optical transparency of the phantoms with temperature was found to be a stable hysteretic behavior and reproducible in consecutive heating–cooling cycles, demonstrating the reusability of the phantoms. By processing the optical images of the phantoms at different stages of the heating process, a thermal lesion can be considered formed (i.e., threshold temperature reached) when the grayscale value reaches the half-saturation point. The image processing method proposed for the NIPAM-based hydrogel phantoms is shown to be independent on the type of heating device used.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Thermal Engineering - Volume 62, Issue 2, 25 January 2014, Pages 322–329
نویسندگان
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