Complexes of DNA with peptide derivatives of cisPt. Electroanalytical examination

The aquation of the core of two novel cisPt complexes led to the formation of diaquated and monoaquated forms for two examined Pt complexes with peptides. DNA extent of DNA platination by novel cisPt derivatives was estimated. This extent was dependent on base-sequence in DNA and type of cisPt complex. The electroreduction of the novel Pt complexes and their adducts with DNA at a GC electrode led to the formation of Pt nanoparticles. In consequence catalytic hydrogen evolution (HER) currents appeared; they were characterized in function of DNA platination extent and size, distribution and mass of electrodeposited Pt NPs. Linear relations were obtained for catalytic HER current and mass of electrodeposited Pt NPs vs. extent of DNA platination for novel peptide cisPt compounds. They have electroanalytical significance.

The linear relations obtained for catalytic hydrogen evolution currents related to electrodeposited Pt NPs on electrode surface plotted vs. extent of DNA platination. They have analytical significance and enable estimation of extent of interaction of cisPt derivatives (AG99p and AG91p) with DNA.96