کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6482239 | 1415982 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combining engineering strategies and fermentation technology to enhance docosahexaenoic acid (DHA) production from an indigenous Thraustochytrium sp. BM2 strain
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The DHA productivity of Thraustochytrium sp. BM2 was improved by optimizing the bioreactor operation conditions. The effects of agitation rate and aeration rate on the microalgal growth and DHA production were first studied in 5-L stirred-tank fermenter. The results showed that 100â¯rpm agitation and 1.2â¯vvm aeration (i.e., kLaâ¯=â¯27â¯Â±â¯1.1â¯hâ1) achieved the highest biomass (4590â¯mg/L/d) and DHA (379â¯mg/L/d) productivities. Next, using an optimal glucose concentration (60â¯g/L) led to the highest biomass (5580â¯mg/L/d) and DHA (457â¯mg/L/d) productivities. The cellular DHA content decreased when increasing the agitation rate, probably due to the sensitivity of this strain to the shear stress. The effect of pneumatic and mechanical agitation under the same kLa was studied with two different types of fermenters (stirred-tank and air-lift) and cultivation in air-lift fermenter resulted in better biomass production (27.57â¯g/L), cellular DHA content (13.1%) and DHA productivity (610â¯mg/L/d).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 133, 15 May 2018, Pages 179-185
Journal: Biochemical Engineering Journal - Volume 133, 15 May 2018, Pages 179-185
نویسندگان
Chun-Yen Chen, Ya-Ting Yang,