Chitosan layered gold nanorods as synergistic therapeutics for photothermal ablation and gene silencing in triple-negative breast cancer

Treatment options for triple-negative breast cancer (TNBC) are limited, as patients do not respond to endocrine or targeted therapies, making this a difficult disease to treat. Multifunctional Chit-Au NRs were fabricated using a layer-by-layer assembly approach for delivery of siRNA gene silencing agents and thermal therapy to TNBC cells. This platform successfully suppressed oncogene expression in vitro and in vivo, resulting in anticancer activity, which was further enhanced through NIR irradiation.286