Controlled chondrogenesis from adipose-derived stem cells by recombinant transforming growth factor-β3 fusion protein in peptide scaffolds

The addition of matrix metalloproteinases (MMPs) can trigger the long-term stable release of mTGF-β3 from the recombinant fusion protein of LAP-MMP-mTGF-β3 in the combined scaffolds, thus stimulating the differentiation of ADSCs into cartilage, which was confirmed by histological analysis, indicating the great potential of this hybrid in rapid therapy of osteoarthritis.78