کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6484106 | 169 | 2013 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Scale-up of docosahexaenoic acid production in fed-batch fermentation by Schizochytrium sp. based on volumetric oxygen-transfer coefficient
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The scale-up of fed-batch fermentation process for the DHA (docosahexaenoic acid)-rich microbial lipids production by Schizochytrium sp. from shake flasks to bench-scale (10 l and 50 l) and pilot-scale (1500 l and 7000 l) stirred fermentors was studied. The fermentation process was successfully scaled-up from experimental-scale to bench-scale and pilot-scale at matched KLa value (88.9 hâ1) estimated by the KLa model developed in this study and the KLa empirical equations. The fermentation performances of the bench-scale and pilot-scale (DHA content of 13.96, 14.44 and 14.16 g lâ1 in the 10 l, 50 l and 1500 l fermentor) processes were similar to that of the experimental-scale process (DHA content of 13.84 g lâ1) and the fermentation results obtained in the 7000 l stirred fermentors (DHA content of 19.72 g lâ1) were much higher. These results indicated that KLa was applicable for the scale-up of the fed-batch fermentation process of DHA production by Schizochytrium sp. and this scale-up strategy enabled a maximum of 150-fold quantitative scale-up of the fed-batch fermentation process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 77, 15 August 2013, Pages 82-87
Journal: Biochemical Engineering Journal - Volume 77, 15 August 2013, Pages 82-87
نویسندگان
Liang Qu, Lu-Jing Ren, He Huang,