کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6486640 | 1416257 | 2018 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of high butanol tolerance and production in clostridia
ترجمه فارسی عنوان
تجزیه و تحلیل تطبیقی تحمل به بوتانول بالا و تولید در کلوستریدیا
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کلمات کلیدی
SMNN-methyl-N′-nitro-N-nitroso-guanidineM4CGGDCSMRTMTaseNTGANIHspEMSFBANGSABE5-methyl cytosine - 5-متیل سیتوزینm5C - m5cm6A - m6aethidium bromide - اتیدیوم برومایدFlux balance analysis - تجزیه و تحلیل تعادل شارButanol tolerance - تحمل بوتانولABE fermentation - تخمیر ABERestriction modification - تغییر محدودیتNext generation sequencing - توالی نسل بعدیButanol production - تولید بوتانولRex - رکسTranscription factor - عامل رونویسیFlow cytometry - فلوسیتومتریTranscriptomics - متن ترانهMethyl transferase - متیل ترانسفرازGenome mining - معدن ژنومaverage nucleotide identity - هویت نوکلئوتیدی متوسطTranscription unit - واحد رونویسیHeat shock protein - پروتئین شوک حرارتPropidium iodide - پروتئین یدیدGenre - ژانرGSM - کلوب جی اس امClostridium - کلوستریدیوم
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
2016, was the 100Â years anniversary from launching of the first industrial acetone-butanol-ethanol (ABE) microbial production process. Despite this long period and also revival of scientific interest in this fermentative process over the last 20Â years, solventogenic clostridia, mainly Clostridium acetobutylicum, Clostridium beijerinckii, Clostridium saccharoperbutylacetonicum and Clostridium pasteurianum, still have most of their secrets. One such poorly understood mechanism is butanol tolerance, which seems to be one of the most significant bottlenecks obstructing industrial exploitation of the process because the maximum achievable butanol concentration is only about 21Â g/L. This review describes all the known cellular responses elicited by butanol, such as modifications of cell membrane and cell wall, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, and also maps both random and targeted mutations resulting in high butanol production phenotypes. As progress in the field is inseparably associated with emerging methods, enabling a deeper understanding of butanol tolerance and production, progress in these methods, including genome mining, RNA sequencing and constructing of genome scale models are also reviewed. In conclusion, a comparative analysis of both phenomena is presented and a theoretical relationship is described between butanol tolerance/high production and common features including efflux pump formation/activity, stress protein production, membrane modifications and biofilm growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 36, Issue 3, MayâJune 2018, Pages 721-738
Journal: Biotechnology Advances - Volume 36, Issue 3, MayâJune 2018, Pages 721-738
نویسندگان
Petra Patakova, Jan Kolek, Karel Sedlar, Pavlina Koscova, Barbora Branska, Kristyna Kupkova, Leona Paulova, Ivo Provaznik,