کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6486701 1416260 2017 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chassis and key enzymes engineering for monoterpenes production
ترجمه فارسی عنوان
مهندسی شاسی و آنزیم کلیدی برای تولید مونوترپنس
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Microbial production of monoterpenes is often limited by their cytotoxicity and in vivo conversion. Therefore, alleviating cytotoxicity and reducing conversion by chassis engineering are highly desirable. On the other hand, engineering key enzymes is also critical for improving monoterpenes production through facilitating the biosynthesis process. Here we critically review recent advances in cytotoxicity alleviation, reducing in vivo conversion, selecting geranyl diphosphate synthase and engineering monoterpene synthases. These achievements would lead to the development of superior chassis with improved tolerance to cytotoxicity and rationally tailored metabolites profiles to improve titer, yield and productivity for the production of monoterpenes by microbial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 35, Issue 8, December 2017, Pages 1022-1031
نویسندگان
, , , , , , , ,