A model for the proteolytic regulation of LpxC in the lipopolysaccharide pathway of Escherichia coli

- Simulation of the first two reactions in the LPS pathway.
- Kinetic parameters were obtained from the literature whilst others were estimated from our simulations.
- The possibility of the unfavourable equilibrium constant in the first step of the LPS pathway was analyzed.
- The mechanism of LpxC regulation by FtsH activation was investigated using differential time trigger in our model.
- Under extreme increases in LpxC concentration, FtsH is incapable of regulating production of excess end-product.