Synthesis and characterization of highly stable superparamagnetic CoFe2O4 nanoparticles as a catalyst for novel synthesis of thiazolo[4,5-b]quinolin-9-one derivatives in aqueous medium

• Synthesis and characterization of highly stable superparamagnetic CoFe2O4 NPs.
• CoFe2O4 MNPs were prepared using a sonochemical in aqueous medium.
• CoFe2O4 MNPs an environmentally benign for synthesis of thiazolo-quinolin-9-one.
• The products easy work-up and the purification by non-chromatographic methods.
• This protocol avoiding hazardous organic solvents and toxic catalysts, reusability.

A highly stable CoFe2O4 magnetic nanoparticles (MNPs) has been successfully prepared using a combined sonochemical and co-precipitation technique in aqueous medium without any surfactant or organic capping agent. The prepared (MNPs) were characterized with XRD, SEM, EDX, TEM, FT-IR and VSM. These nanoparticles form stable dispersions in aqueous or alcoholic medium. MNPs has been an efficient and environmentally benign nanocatalyst for the one-pot multicomponent synthesis of tetrahydrobenzo[h][1,3] thiazolo[4,5-b]quinolin-9-one 4a-p. The synthesized compounds easy work-up and purification of products by non-chromatographic methods. Highly yield of the corresponding products were obtained within a very short time in presence of just 6 mol% of the catalyst.

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