Palladium-catalyzed direct CH arylation of 2-hydroxybenzaldehydes with organic halides in neat water

• Palladium-catalyzed CH bond functionalization of 2-hydroxybenzaldehydes.
• CC bond formation of 2-hydroxybenzaldehydes with aryl halides.
• Excellent efficiency of reaction in water as a green solvent.
• An efficient method for the reaction of aryl bromides with 2-hydroxybenzaldehydes.

The palladium-catalyzed cross-coupling of 2-hydroxybenzaldehydes with organic halides proceeds in the presence of n-Bu4NBr in H2O producing the corresponding 2-hydroxybenzophenones in high yields.

The palladium-catalyzed cross-coupling of 2-hydroxybenzaldehydes with organic halides proceeds in H2O to give the corresponding 2-hydroxybenzophenones.Figure optionsDownload high-quality image (106 K)Download as PowerPoint slide