Elucidating steric effects on enantioselective epoxidation catalyzed by (salen)Mn in metal-organic frameworks

▶ Interpenetration of a metal-organic framework leads to lower enantioselectivity of (salen)Mn. ▶ The framework restricts the approach of chromene to the (salen)Mn ▶ The framework restricts conformational changes associated with high enantioselectivity.