Mo/γ-Al2O3 catalysts for the Biginelli reaction. Effect of Mo loading

• xMo/Al2O3 catalysts (x = 2–12 wt%) are tested in Biginelli reaction for DHPM.
• XRD and FFT analysis revealed the presence of Al2(MoO4)3 phase on Mo/γ-Al2O3.
• Al2(MoO4)3 phase could be responsible to generated Brønsted acid sites.
• DHPM formation is related to Brønsted acid sites and Al2(MoO4)3 phase.
• Mo/Al2O3 catalysts are highly stable and reusable materials for Biginelli reaction.

Alumina supported Mo catalysts with varying metal loading (2–12 wt%) were tested in the Biginelli reaction under solvent free conditions for synthesis of 3,4-dihydropyrimidin-2-(1H)-one (DHPM). The DHPM yield increased with Mo loading, going through a maximum for 7 wt% Mo. Alumina supported Mo catalysts appeared to be highly stable and reusable materials for this reaction.A suite of characterization techniques that included X-ray diffraction, Fast Fourier Transform analysis and FTIR of adsorbed pyridine revealed that the DHPM formation is related to the existence of Brønsted acid sites that would be linked to the presence of Al2(MoO4)3 phase.

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