کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6555433 | 1422482 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clofazimine drug susceptibility testing for Mycobacterium tuberculosis: the case of using the right diluent
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی قانونی
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چکیده انگلیسی
Accurate and reliable drug susceptibility testing (DST) is essential for the effective treatment and control of tuberculosis. With the increase in drug-resistant organisms, newer and less conventional antimicrobial agents are used for treatment. Recently, we found an unprecedented rise in the number of clofazimine-resistant Mycobacterium tuberculosis isolates in our laboratory. An investigation found that this phenomenon was due to a change in the method of drug preparation. We performed studies to assess the impact of water and dimethyl sulfoxide (DMSO) as a final diluent for clofazimine drug testing. Based on our findings, the use of DMSO as a solvent for M. tuberculosis DST was optimised using the BACTEC MGIT 960 platform.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 50, Issue 5, August 2018, Pages 549-553
Journal: Pathology - Volume 50, Issue 5, August 2018, Pages 549-553
نویسندگان
Li-Hwei Sng, Justine Woei Ling Peh, Melody Tai Lee Kee, Nurhazirah bte Mohd Ya'akob, Rick Twee-Hee Ong, Christopher W. Wong, Cynthia Bin Eng Chee, Yee Tang Wang,