کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6579992 1422937 2018 45 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Construction of highly biocompatible hydroxyethyl cellulose/soy protein isolate composite sponges for tissue engineering
ترجمه فارسی عنوان
ساخت اسفنج کامپوزیت جداسازی پروتئین هیدروکسی اتیل سلولز / سویا بسیار سازگار با محیط زیست برای مهندسی بافت
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کلمات کلیدی
هیدروکسی اتیل سلولز، پروتئین سویا، اسفنج ها، متخلخل زیست سازگاری،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی
In this study, ethylene glycol diglycidyl ether (EGDE)-crosslinked hydroxyethyl cellulose (HEC)/soy protein isolate (SPI) composite sponges (EDHSS) were constructed by the combination of blending, crosslinking and freeze-drying. The sponges were characterized by FTIR, wide-angle X-ray diffraction (XRD), solid-state 13C NMR, scanning electron microscopy (SEM) and mechanical testing. The results indicated that crosslinking interactions occurred in the inter- and intra-molecules of HEC and SPI during the fabrication process. EDHSS exhibited uniformly inter-connected porous structure on their surfaces and cross-sections (average pore size ≥220 μm) and good mechanical property, indicating certain miscibility between HEC and SPI. Cytocompatibility, degradability, hemocompatibility and initial bioactivity of EDHSS were evaluated by a series of in vitro experiments. MTT assay and cell culture experiment results showed that EDHSS had good biocompatibility, and L929 cells could adhere on almost everywhere of the surface and enter their interiors. The results of blood coagulation routine, hemolysis testing, red blood cell incubation experiment and blood absorption testing indicated that EDHSS had good hemocompatibility and no significant side-effects on the anticoagulation of whole blood. Moreover, EDHSS exhibited in vitro degradability and certain in vitro bioactivity. Therefore, EDHSS had potential application as biomaterials that may contact with blood or as scaffold for tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 341, 1 June 2018, Pages 402-413
نویسندگان
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