Microwave-accelerated three components cyclocondensation in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones promoted by Cu-CNTs

Cu-CNTs efficiently catalyzes condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium acetate to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives successfully in high yield. The protocol proves to be efficient and environmentally benign in terms of very easy work-up, high yields, and ease of recovery of catalyst. In addition, the present method is superior in terms of green media, the amount of catalyst and reaction time.

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► High yields, short reaction times, recyclability of the catalyst, and simple work-up procedures.
► 0.04 g Cu-CNTs was the optimum amount in yield of quinazolinones.
► The reaction at power 65 and 5 min proceeded in highest yield.