کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
658750 1458089 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Visualization of electroporation-induced temperature rise using temperature-sensitive ink
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Visualization of electroporation-induced temperature rise using temperature-sensitive ink
چکیده انگلیسی
Irreversible electroporation (IRE) is attracting attention as a new technique to treat tumors, in which electric pulses over a certain threshold perforate the cell membrane and induce necrotic cell death. Since the electric pulses potentially generate the Joule heating around electrodes, successful IRE needs to apply a pulsed voltage high enough for the irreversible perforation yet minimizes the thermal effect on the extracellular matrix in the surrounding tissue. The temperature rise around the electrodes is therefore one of the most important concerns in the IRE. However, no experimental evidence has been reported for the temperature rise because of extremely short pulses used in the IRE. The aim of this study was therefore to establish a new method to detect the temperature rise during the IRE. A key technique is to use temperature-sensitive ink to visualize in situ instantaneous temperature rise. Chromatic change of the ink that depends on the temperature was preliminarily calibrated by a transient short-hot-wire technique combined with color analysis of the ink, and then utilized to determine the temperature distribution after electroporation. The maximum temperature rise was thus successfully visualized after the electroporation using agar gel as a tissue phantom. Our method is useful for direct evaluation of a risk of thermal damage and provides experimental evidence for theoretical study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Heat and Mass Transfer - Volume 55, Issues 23–24, November 2012, Pages 7207-7212
نویسندگان
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