کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6588130 | 456474 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous flow azide formation: Optimization and scale-up
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
The intrinsically small volumes and highly controlled reaction conditions render continuous flow microreactors ideal systems for the synthesis of potentially explosive compounds such as organic azides. In this article, we report the formation of benzyl azide from benzylamine using imidazole-1-sulfonyl azide hydrochloride as diazotransfer reagent. In a small scale (semi-automated) continuous flow setup the diazotransfer reaction was optimized using minimal amounts of reagents; less than 400Â mg of benzylamine was required to perform 60 optimization reactions. The optimal reaction conditions were indentified to be room temperature, 600Â s of residence time and an imidazole-1-sulfonyl hydrochloride to benzylamine stoichiometric ratio of 3 to 4. Furthermore, we successfully scaled up the reaction with a factor of 200 to gram scale using one single continuous flow reactor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 167, Issues 2â3, 1 March 2011, Pages 556-559
Journal: Chemical Engineering Journal - Volume 167, Issues 2â3, 1 March 2011, Pages 556-559
نویسندگان
Mariëlle M.E. Delville, Pieter J. Nieuwland, Paul Janssen, Kaspar Koch, Jan C.M. van Hest, Floris P.J.T. Rutjes,