کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6595487 458534 2015 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gobal optimization of hybrid kinetic/FBA models via outer-approximation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Gobal optimization of hybrid kinetic/FBA models via outer-approximation
چکیده انگلیسی
Flux balance analysis (FBA) is a linear programming-based framework widely used to predict the behavior, in terms of the resulting flux distribution, of cellular organisms in different media. FBA models are constructed using only stoichiometric information, and for this reason they sometimes fail in predicting fluxes precisely. In this work, we formally define the concept of hybrid FBA/kinetic models, in which kinetic information of key processes is used to tighten the search space of standalone FBA formulations, thereby enhancing their predictive capabilities. This approach leads to non-linear non-convex models that may exhibit multiple local optima. To solve them to global optimality, we use a customized outer-approximation algorithm that exploits the structure of the kinetic equations. Numerical results show that our method enhances the quality of standalone FBA models, providing more accurate predictions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 72, 2 January 2015, Pages 325-333
نویسندگان
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