کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6595640 | 458533 | 2014 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Global superstructure optimisation of red blood cell production in a parallelised hollow fibre bioreactor
ترجمه فارسی عنوان
بهینه سازی فوق العاده ساختمانی جهانی تولید گلبول قرمز در یک بیوراکتور فیبر توخالی موازی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Recent work developed a novel, biomimetic, cost-effective three-dimensional hollow fibre bioreactor for growing healthy red blood cells ex vivo (Panoskaltsis et al., 2012). This bioreactor recapitulates architectural and functional properties of erythrocyte formation and thereby reduces the need for expensive growth factors by more than an order of magnitude. Individual experiments to empirically improve the bioreactor are intensive, so we propose global superstructure optimisation for bioreactor design. Our approach integrates topological design choices with operating conditions. Design choices include: number of parallelised bioreactors; number and type of hollow fibres; size and aspect ratio. Operating conditions are: feed concentrations; flowrate through the reactor. This manuscript quantitatively demonstrates, for the first time, the potential for ex vivo red blood cell production to compete openly against the transfusion market for rare blood. We discuss the potential of superstructure design not only on this individual bioreactor but also more generally on bioprocess optimisation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 71, 4 December 2014, Pages 532-553
Journal: Computers & Chemical Engineering - Volume 71, 4 December 2014, Pages 532-553
نویسندگان
Ruth Misener, MarÃa Fuentes GarÃ, Maria Rende, Eirini Velliou, Nicki Panoskaltsis, Efstratios N. Pistikopoulos, Athanasios Mantalaris,