کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
660824 1458141 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted brain hypothermia induced by an interstitial cooling device in the rat neck: Experimental study and model validation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Targeted brain hypothermia induced by an interstitial cooling device in the rat neck: Experimental study and model validation
چکیده انگلیسی

Targeted brain hypothermia has the potential to prevent cerebral ischemia injury during open heart and neck surgeries or after traumatic head injury. In this study, in vivo experiments were performed to test the performance of a newly developed cooling device in an inexpensive animal model. Rat brain hypothermia was induced by inserting an interstitial cooling device in the rat neck muscle and placing the device on the common carotid artery to cool the arterial blood supplied to the brain. Coolant was circulating inside the cooling device to achieve either mild or moderate temperature reductions at the surface of the device. Temperatures were measured inside the rat brain tissue, as well as on the head skin surface. For the mild cooling (cooling device surface temperature was 18.7 ± 4.5 °C), the temperature reductions were 2.2 ± 0.6 °C, 2.1 ± 0.6 °C, 1.9 ± 0.6 °C and 1.6 ± 0.9 °C at sites of brain-5 mm, brain-2 mm, skull, and scalp, respectively. After the surface temperature was further decreased to 12.8 ± 2.8 °C (moderate cooling), the temperature reduction in the head increased more than 85% to 3.7 ± 3.2 °C, 3.7 ± 3.0 °C, 3.3 ± 2.5 °C and 2.5 ± 1.0 °C, respectively. The experimental data were also used to validate a previously developed theoretical model for humans. Experimentally measured geometrical and physiological parameters of the rat neck and brain were substituted into the scaled-down theoretical model to simulate the temperature distribution in the rat neck and brain. The theoretically predicted brain temperatures showed a good agreement with the experiment data. We believe that this study is the first step in developing a reliable cooling device to achieve fast cooling and to control rewarming in future clinical studies and to benefit a large patient population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Heat and Mass Transfer - Volume 51, Issues 23–24, November 2008, Pages 5662–5670
نویسندگان
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