کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6615400 | 459622 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of the size of receptor in allergy detection using field effect transistor biosensor
ترجمه فارسی عنوان
اثر اندازه گیرنده در تشخیص آلرژی با استفاده از میدان بیوسنسور ترانزیستور اثر میدان
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Allergy diagnosis, conducted to determine whether a specific syndrome is attributable to allergy, plays a significant role in the overall health examination. In this paper we report that the detection of allergy-associated protein, immunoglobulin E (IgE), was achieved by using field effect transistors (FETs) immobilized with an antigen as a receptor, which is smaller in size than the conventional receptor (antibody). The antigen-immobilized FETs exhibit a higher response to IgE than the antibody-immobilized FETs, suggesting that the smaller receptor not only makes the more effective use of the charge-detectable region for the FET-based detection in terms of Debye length, but also provides more recognition sites for target molecules and greater ability to block nonspecific adsorption of non-related proteins because of the closely-packed immobilized receptors. In addition, the application of the antigen to FET biosensor gives an advantage in the identification of the specific allergen. These results show that the small receptor of antigen is more effective than the antibody in the allergy detection using FET biosensors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 110, 1 November 2013, Pages 146-151
Journal: Electrochimica Acta - Volume 110, 1 November 2013, Pages 146-151
نویسندگان
Sho Hideshima, Shigeki Kuroiwa, Marika Kimura, Shanshan Cheng, Tetsuya Osaka,