کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6660517 | 1426228 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermodynamics of the solubility of reserpine in {{2-(2-ethoxyethoxy)ethanol + water}} mixed solvent systems at different temperatures
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Thermodynamics of solubility of the bioactive compound reserpine in various {2-(2-ethoxyethoxy)ethanol + water} mixed solvent systems was investigated in this study. The solubility of reserpine was determined from T = (298.15 to 338.15) K at atmospheric pressure using the reported method of Higuchi and Connors. Values of the measured solubility of reserpine were correlated with the ideal and Yalkowsky models. The root mean square deviations (RMSD) were observed to be less than 0.020 by an ideal model. However, the RMSD values were observed as less than 0.050 by the Yalkowsky model. The mole fraction solubility of reserpine was observed highest in pure 2-(2-ethoxyethoxy)ethanol (7.69 · 10â4 at T = 298.15 K) and lowest in pure water (9.71 · 10â7 at T = 298.15 K) at each temperature investigated. The results of the Van't Hoff and Krug analysis (thermodynamic studies) indicated endothermic and spontaneous dissolution of reserpine in all {2-(2-ethoxyethoxy)ethanol + water} mixed solvent systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Chemical Thermodynamics - Volume 85, June 2015, Pages 57-60
Journal: The Journal of Chemical Thermodynamics - Volume 85, June 2015, Pages 57-60
نویسندگان
Faiyaz Shakeel, Nazrul Haq, Nasir A. Siddiqui, Fars K. Alanazi, Ibrahim A. Alsarra,