کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6661523 | 1426551 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sensitive electrochemical cytosensor for highly specific detection of osteosarcoma 143B cells based on graphene-3D gold nanocomposites
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sensitive electrochemical cytosensor for highly specific detection of osteosarcoma 143B cells based on graphene-3D gold nanocomposites Sensitive electrochemical cytosensor for highly specific detection of osteosarcoma 143B cells based on graphene-3D gold nanocomposites](/preview/png/6661523.png)
چکیده انگلیسی
A novel electrochemical cytosensor was developed for detection of human osteosarcoma 143B cells based on graphene-three dimensional nanostructure gold nanocomposites (G-3D Au) using facile and rapid one-step electrochemical co-reduction technique. Characterizations by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that the gold nanoparticles in the scale of about 5-80â¯nm were deposited on the graphene sheets - showing pinecone-like 3D gold nanostructures. The proposed cytosensor, due to the increasing surface area and enhanced electron transfer rate by the nanocomposite, provided a highly stable and efficient matrix for the convenient conjugation of target CXCR4 antibody and the following incubation of cells. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) showed that the developed cytosensor was able to detect 143B cells ranging from 5.0â¯Ãâ¯103 to 5â¯Ãâ¯106â¯cellsâ¯mLâ1 with a lower detection limit of 1292â¯cellsâ¯mLâ1. This electrochemical cytosensor showed a fast response, high sensitivity and selectivity, which could be used in various applications such as cancer diagnosis, drug screening and cell adhesion studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 824, 1 September 2018, Pages 108-113
Journal: Journal of Electroanalytical Chemistry - Volume 824, 1 September 2018, Pages 108-113
نویسندگان
Zhao-Yang Wu, Jin-Yuan Chen, Xia Zhu, Fei-Huan Fu, Rui-Long Lan, Meng-Meng Liu, Xin Lian, Chen-Liu Ye, Guang-Xian Zhong, Jian-Hua Lin, Ai-Lin Liu,