کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
67161 | 48468 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor](/preview/png/67161.png)
Double carbonylation of iodobenzene in the presence of amines were carried out effectively in a microfluidics-based flow reactor (X-Cube™) of high throughput capability using immobilized Pd(PPh3)4 catalyst. By the proper tuning of the reaction conditions α-ketoamides could be synthesized with 70–96% selectivities depending on the choice of the nucleophile. The highest yields of double carbonylation products were obtained at relatively low temperature (80 °C) and using DBU as the base with primary amines as the reaction partners. Imine formation was observed only at higher temperatures.
Double carbonylation of iodobenzene in the presence of amines were carried out effectively in a microfluidics-based flow reactor (X-Cube™) of high throughput capability using immobilized Pd(PPh3)4 catalyst. By the proper tuning of the reaction conditions α-ketoamides could be synthesized with 70–96% selectivities depending on the choice of the nucleophile. The highest yields of double carbonylation products were obtained at relatively low temperature (80 °C) and using DBU as the base with primary amines as the reaction partners. Imine formation was observed only at higher temperatures.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 302, Issues 1–2, 1 April 2009, Pages 76–79