کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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67405 | 48481 | 2009 | 7 صفحه PDF | دانلود رایگان |
The study describes the first catalytic application of iron phosphinooxazoline complexes and Fe(OTf)2 in oxidation reactions. New iron phosphinooxazoline (PHOX) complexes of the general formulation [Fe(PHOX)2]2+[OTf]2 (3, OTf = CF3SO3−) were synthesized in virtually quantitative yield from anhydrous Fe(OTf)2 and the corresponding PHOX ligands. The new complexes 3 as well as previously synthesized iron PHOX complexes of the general formula [Fe(Cp)(CO)(PHOX)]+[I]− (2) were employed as catalysts in the oxidation of benzylic CH2 groups to the corresponding ketones. Whereas 3 showed catalytic activity at room temperature (about two equivalents t-BuOOH as the oxidant, 2 mol% catalyst, pyridine solvent, 12 h, 38–93% isolated yields), complexes of 2 were only active at elevated temperatures. The product profile is in accordance with a mechanism previously described as “oxygenated Fenton chemistry”, which is further corroborated by UV–vis investigations. They showed that an iron alkylperoxo species [Fe–OOtBu] might be involved in the catalytic cycle. The reaction follows a pseudo zero order rate law in substrate.
Novel iron phosphinooxazoline complexes were synthesized and their catalytic activity in the oxidation of benzylic methylene groups was investigated. At a catalyst load from 2 to 5%, isolated yields ranged from 38 to 93%. The reaction presumably proceeds through a Fenton type mechanism and is pseudo zero order in substrate.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 309, Issues 1–2, 18 August 2009, Pages 117–123