کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6794748 | 540699 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PSA-NCAM in the posterodorsal medial amygdala is necessary for the pubertal emergence of attraction to female odors in male hamsters
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کلمات کلیدی
PVPPSAMePDMesocricetus auratusPSA-NCAMMEALHbHabenula - habenulaMedial habenula - habenula پزشکیMHb - MHBmedial amygdala - آمدیگدال medialPolysialic acid - اسید نیتریکPuberty - بلوغ جنسیThalamus - تالاموسstria terminalis - ترمینال استریtestosterone - تستوسترونSexual attraction - جاذبه جنسیlateral habenula - حنابا جانبیdentate gyrus - شکنج دندانه دارSON - فرزند پسرneural cell adhesion molecule - مولکول چسبندگی سلولی عصبیpolysialylated neural cell adhesion molecule - مولکول چسبندگی سلولی عصبی پلیسیسیله شدهMale - نرSupraoptic nucleus - هسته Supraopticbed nucleus of the stria terminalis - هسته تخت ترمینال های استریNeural plasticity - پلاستیک عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
During puberty, attention turns away from same-sex socialization to focus on the opposite sex. How the brain mediates this change in perception and motivation is unknown. Polysialylated neural cell adhesion molecule (PSA-NCAM) virtually disappears from most of the central nervous system after embryogenesis, but it remains elevated in discrete regions of the adult brain. One such brain area is the posterodorsal subnucleus of the medial amygdala (MePD). The MePD has been implicated in male sexual attraction, measured here as the preference to investigate female odors. We hypothesize that PSA-NCAM gates hormone-dependent plasticity necessary for the emergence of males' attraction to females. To evaluate this idea, we first measured PSA-NCAM levels across puberty in several brain regions, and identified when female odor preference normally emerges in male Syrian hamsters. We found that MePD PSA-NCAM staining peaks shortly before the surge of pubertal androgen and the emergence of preference. To test the necessity of PSA-NCAM for female odor preference, we infused endo-neuraminidase-N into the MePD to deplete it of PSAs before female odor preference normally appears. This blocked female odor preference, which suggests that PSA-NCAM facilitates behaviorally relevant, hormone-driven plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 75, September 2015, Pages 91-99
Journal: Hormones and Behavior - Volume 75, September 2015, Pages 91-99
نویسندگان
Martin O. Job, Bradley M. Cooke,